Diurnal sedative changes during intensive care

Diurnal sedative changes during intensive care: impact on liberation from mechanical ventilation and delirium.

OBJECTIVE To determine whether benzodiazepine and propofol doses are increased at night and whether daytime and nighttime sedative doses are associated with delirium, coma, and delayed liberation from mechanical ventilation. DESIGN Single-center, prospective cohort study nested within the Awakening and Breathing Controlled randomized trial. SETTING Saint Thomas Hospital in Nashville, TN, fr...

Free radical and drug oxidation products in an intensive care unit sedative: propofol with sulfite.

OBJECTIVES Some propofol emulsion formulations contain EDTA or sodium metabisulfite to inhibit microbe growth on extrinsic contamination. EDTA is not known to react with propofol formulation components; however, sulfite has been shown to support some oxidation processes and may react with propofol. This study compared the oxidation of propofol and the formation of free radicals by electron para...

Sedative and analgesic practice in the intensive care unit: the results of a European survey.

Sedation and analgesia are important aspects of patient care on the intensive care unit (ICU), yet relatively little information is available on common sedative and analgesic practice. We sought to assess international differences in the prescription of sedative and analgesic drugs in western European ICUs by means of a short, self-administered questionnaire. Six hundred and forty-seven intensi...

Maintenance of metabolism during intensive patient care.

Measurement and recording during intensive patient care.

ANY PROBLEM in clinical measurement involves an analysis of the medical requirements in order to assess what information is to be obtained and how it is to be used. This approach is quite general. The Clinical Measurement Department at Westminster Hospital is a service department organized under the National Health Service and is concerned with a wide variety of clinical measurements ranging fr...